Little change in colonic B cells was observed after IL-1β blockade in Fcgr2b−/− mice (Figure S6J); however, there was a reduction in the severity of colitis (Figure 6H) and colonic neutrophil infiltration (Figure 6I), directly implicating this pathway in detrimental immune responses driven by dysregulated FcγR signaling. Here, FCGR2A is linked to colitis.