Based on correlations between CpG site methylation and miRNA expression from this locus in APL, in addition to the roles for this locus in HSC stemness maintenance and leukemic cell proliferation, we hypothesized that patients’ response to chemotherapy and overall survival would depend on CpG site methylation and imprinted gene expression from the DLK1-MEG3 locus. This evidence concerns the gene MEG3 and acute promyelocytic leukemia.