MEG3 and acute myeloid leukemia: To investigate the relationship between methylation at the DLK1-MEG3 locus and patient outcomes in AML, we assessed the methylation of four CpG sites within this locus (Fig. 1a) in AML patient peripheral blood mononuclear cells (MNCs) and compared our results with patient overall survival (OS) and first-round induction therapy response (IR).