While this is consistent with the growth-promoting effects of DLK1 on leukemic cells, our data for MEG3 alludes to the presence of underlying miRNA signatures from this locus which may overcome the tumor-suppressing abilities of MEG3. In support of this, the negative correlation we observed between CG7 methylation and MEG3 expression is consistent with the recent work of Yao et al. [29] in AML patients from a Hainan population and supported by work by Merkerova et al. which observed increased MEG3 expression in MDS/AML-MR patients with shorter OS [43]. The gene discussed is DLK1; the disease is myelodysplastic syndrome.