MESD and colorectal carcinoma: More recently, we have developed a highly sensitive and accurate methylation DNA assay consisting of quantitative methylation-specific real-time PCR (qMSP) following linear target enrichment (LTE) (named as meSDC2 LTE-qMSP) for SDC2 methylation and demonstrated that SDC2 methylation test in stool DNA has high potential as a diagnostic method for early detection of CRC [16].