TM4SF1 and malignant colon neoplasm: Otsuka et al. [17] applied internal cDNA microarray technology to detect genetic changes in colon cancer cell lines (SW 480 and SW 620) and 58 cases of clinically stratified colorectal cancer tissues, and the results showed that TM4SF1 gene expression was closely associated with the progression of tumor stage and might be a potential marker of metastasis.