The value of TM4SF1 as a target for anti-tumor therapy was investigated in this study by examining the expression of TM4SF1 in ovarian cancer tissues and its effects on the biological behaviors of the highly metastatic ovarian cancer cell line HO8910PM and SKOV3 cells and on the growth of xenograft tumors in nude mice. Here, TM4SF1 is linked to ovarian carcinoma.