PRKCA and breast carcinoma: A recent study showed that TM4SF1 could interact with discoidin domain receptor 1 (DDR1) promoted by collagen I. In addition, TM4SF1 could recruit syntenin2 and PKCa and activate PKCa to induce the noncanonical DDR1 signaling pathway to regulate metastasis of dormant breast cancer cells to multiple distant tissues [20].