An important milestone in the treatment of NSCLC was the discovery of epidermal growth factor receptor (EGFR)-activating mutations as an effective therapeutic target and the successful development of third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs; Gefitinib, erlotinib, afatinib, and osimertinib). Here, EGFR is linked to non-small cell lung carcinoma.