As a key enzyme in lipid metabolism, Stearoyl-CoA Desaturase 1 (SCD1) synthesized saturated fatty acids (SFAs) into monounsaturated fatty acids (MUFAs), which can be further synthesized to neutral lipids such as triglycerides (TG) and stored in organelles termed ‘lipid droplets’ (LDs), and several studies have shown that cancer tissues display a higher rate of lipid droplets than normal tissues in several cancers including NSCLC [10–12]. The gene discussed is SCD; the disease is cancer.