IRF2 and acute myeloid leukemia: Our previous study [13] demonstrated that shRNA-mediated IRF2 knockdown suppressed cell growth and colony formation, down-regulated the level of anti-apoptotic factor Bcl-2 and up-regulated the protein levels of apoptotic proteins Bax and the cleaved caspase 3 in AML cell lines OCI/AML-2, OCI/AML-3, and THP-1 cells.