The drug combinations in nanoparticles have been tested in various treatment strategies in different types of cancers such as a combination of photothermal therapy and anti-CTLA4 (cytotoxic T-lymphocyte-associated antigen 4) encapsulated in PLGA nanoparticle for immunotherapy [64], lipid/calcium/phosphate nanoparticles containing Vascular endothelial growth factor (VEGF) small interfering RNA (siRNA) and gemcitabine monophosphate to treat NSCLC [65], combination of Avastin and BPD (Verteporfin) in liposomes to treat pancreatic cancer [66]. The gene discussed is VEGFA; the disease is cancer.