Lipid metabolism and mitochondrial membrane transporter genes, which are essential for improving cardiac myocyte survival, such as acyl-CoA thioesterase 1 (Acot1), acylCoA oxidase 1 palmitoyl (Acox1), and ubiquinol cytochrome c reductase (Uqcrfs1), were upregulated, whereas fibrosis and inflammatory response genes, which induce cardiac remodeling in cardiac damage, such as SMAD family member 2, 3, and 9 (SMAD2, 3, 9), TIMP metallopeptidase inhibitor 1 (TIMP1), connective tissue growth factor (CTGF), toll-like receptor 3 (TLR3), and TGF-β2, were downregulated in the MI + Fima group. Here, SMAD2 is linked to myocardial infarction.