MiR-451 acts by restraining the activity of LKB1 in a CAB-39-dependent manner and thus leads to weakened AMPK activity (diminished phosphorylation of AMPK itself, Raptor, ACC, TSC2 or increased phosphorylation of RPS6K and RPS6) in GBM cells [62]. The gene discussed is TSC2; the disease is glioblastoma.