Survivin shRNA-encoding plasmid was also delivered to SKOV-3 cells by self-assembled supramolecular micelles composed of b-cyclodextrin-polyethylenimine (PEI600-CyD) and 2-amineadamantine-conjugated PCT (Ada-PCT) by Hu et al. They proved that simultaneously administrated PCT and shRNA at concentrations of 0.6 μg/mL, 2 μg/mL in vitro and 6 μg/animal, 20 μg/animal in vivo, respectively, induces significantly higher cell apoptosis and inhibits tumor growth [163]. The gene discussed is BIRC5; the disease is neoplasm.