EGFR pathway-independent mechanisms include MET amplification, HER2 amplification, FGFR1 amplification, BRAF mutation, KRAS mutation, and histologic transformation to small cell lung cancer [64,65,66,67,68,69,70,71,72,73,74,75,76,77,78]. This evidence concerns the gene ERBB2 and small cell lung carcinoma.