EGFR and non-small cell lung carcinoma: While dacomitinib resulted in an improved overall survival compared to gefitinib in advanced EGFR mutant NSCLC (HR 0.76; 95% CI, 0.58–0.99; p = 0.04), afatinib did not achieve a significant improvement in overall survival compared to gefitinib (HR 0.86; 95% CI, 0.66–1.12; p = 0.26) [47,48].