In this work, we examined the influence of the four NFκB inhibitors Cortisol, MLN4924, QNZ and TPCA1 on proliferation, inflammation and sensitisation to apoptosis mediated by the death ligand FasL in the HNSCC cell lines PCI1, PCI9, PCI13, PCI52 and SCC25 [18] and in the human keratinocyte cell line HaCaT. The gene discussed is FASLG; the disease is head and neck squamous cell carcinoma.