The studied hybrids were 1,2-diphenyl-5,6-dihydropyrrolo-[2,1-α]isoquinoline derivatives, designed as a result of a combination of structures of CA-4 and lamellarin D. Among the compounds tested, hybrid 38 (Figure 13), with two isopropoxy groups at positions 8 and 14 and two hydroxyl groups at positions 20 and 21, was the most active against all cancer cells studied. The gene discussed is CA4; the disease is cancer.