CA4 and cancer: In 2010, twenty-six hybrids of CA-4 and lamellarin D (37) (Figure 13), which proved to be a potent pro-apoptotic agent, were synthesized and evaluated for their antiproliferative activity against five human cancer cell lines: K-562 (leukemia), A-549 (lung carcinoma), SMMC-7721 (hepatocellular carcinoma), SGC-7901 (gastric carcinoma) and HCT-116 (colon carcinoma) [61].