INS and Insulin resistance: We observed a significant increase in fasting insulin levels in mice after BDL in WT mice and KO mice (consistent with insulin resistance that is commonly observed during liver fibrosis/dysfunction [55]), however that increase was completely reversed by IL-1Ra treatment in WT mice (and KO mice) (Supplementary Figure S2), consistently with the known anti-diabetic effect of exogenous IL-1Ra [56].