HK2 and hepatocellular carcinoma: Immunohistochemical analysis of HK-II protein expression in archived tumor specimens from our HCC patient cohort (n = 94) demonstrated that HK-II expression was increased in the tumor tissue of 72 cases (76.6%), whereas 22 cases (23.4%) showed decreased HK-II expression compared to adjacent nonmalignant liver tissue (Table S4, Figure S5).