Accordingly, pre-treatment with TSA, against TRAIL-resistant T24 bladder cancer cells, followed by incubation with TRAIL, resulted in a marked increase of TRAIL-induced apoptosis, due to upregulated TRAIL-R2 expression, thus indicating the combination of TSA and TRAIL as a promising alternative treatment for urothelial bladder cancer therapy [235]. Here, TNFSF10 is linked to urinary bladder cancer.