HDAC1 and urinary bladder neoplasm: Interestingly, in a similar size patient collection, a statistically significant HDAC1, 2, 3 and 8 over-expression was observed for bladder tumors, as compared to normal mucosas, with HDAC1 and 3 being downregulated in deeply invasive and advanced tumors, and HDAC3 being increased in patients characterized by improved survival [165,168].