Microarray studies in T24 bladder cancer cells after vorinostat and trichostatin A treatment demonstrated an upregulation in gene expression for p21WAF1, Hep27, Histone H2B, TRPM2, Gelsolin, α-Tubulin, Glutaredoxin and Metallothionein 1L, and a repression in Thymidylate Synthase, CTP synthase, APRIL and TRP gene expression [224]. The gene discussed is TRPM2; the disease is urinary bladder cancer.