On the other hand, SIRT7 has been previously presented with an upregulated transcriptional activity in bladder carcinomas versus matched normal tissues, with the high-grade and stage tumors being characterized by elevated SIRT7 expression levels, as compared to the low-grade and stage ones [181], thus indicating the enzyme’s critical oncogenic role in urothelial bladder tumorigenesis. This evidence concerns the gene SIRT7 and urinary bladder carcinoma.