Other tumor suppressor genes being inactivated by mutation in MIBC, are the ones encoding the ARID1A, TXNIP, ELF3, NFE2L2, FBXW7, APC, CDKN1A, EP300, TSC1, PTEN, ATM, KMT2D, KLF5 and TSC2 proteins. Here, APC is linked to neoplasm.