SIRT2 and urinary bladder cancer: In the same direction, a specific siRNA-mediated targeting of SIRT2 mRNA, combined with a tubacin-induced inhibition of HDAC6 family member, resulted in significant suppression of bladder cancer cell migration and invasion capacities, strongly supporting their (SIRT2 and HDAC6) cooperative actions and tumor promoting roles in urothelial malignancies [178].