Furthermore, examining a larger cohort of urothelial bladder cancer patients, 40%, 42% and 59% of the tumors were presented with high levels of HDAC1, 2 and 3 protein expression, respectively, with HDAC1 and 2 family members being associated with higher tumor grades, and HDAC1 being tied in with a trend towards poorer prognosis [165,167]. Here, HDAC1 is linked to bladder transitional cell carcinoma.