Baicalein also overcame TNF-related apoptosis-inducing ligand (TRAIL) resistance by enhancing TRAIL-2 promoter activity through induction of CCAAT/enhancer-binding protein homologous protein (CHOP) in human colon cancer SW480 cells or by increasing expression of TRAIL-2 through ROS induction [25]. The gene discussed is DDIT3; the disease is malignant colon neoplasm.