The mechanisms of baicalein in cancers involve activation of autophagy through AMP-activated protein kinase (AMPK)-unc-51-like kinase 1 (ULK), cell cycle arrest by CDC2/Cyclin B1, or induction of apoptosis by inhibition of the PI3K/Akt pathway, transforming growth factor (TGF) signaling, myeloid leukemia 1 (Mcl-1), and mammalian target of rapamycin (mTOR) signaling [41,42,43]. The gene discussed is ULK1; the disease is cancer.