Presently, numerous disease-modifying targeted therapies for TTR amyloidosis are being tested in human clinical trials, including TTR stabilizers (diflunisal, tafamidis), fibril disruptors (doxycycline/TUDCA) and the most recent gene therapies to block TTR expression (small interference RNAs (siRNAs) and antisense oligonucleotides therapy (ASOs)) [26,37,96,97]. Here, TTR is linked to amyloidosis.