Affected genes include ATM, ERCC1, TP53, MDM2, CDKN2A, RB1, CDKN1A, PTEN, CCNE1, FBXW7, CDKN1B, CCND1/2/3, CDK4/6, TSC1, FGFR3, PIK3CA, PPARG, E2F3, EGFR, ERBB2, YAP1, MYC, ZNF703, MYCL1, and BCL2L1. Subsequent studies of some of these genes have confirmed that their altered activity and/or expression level can contribute to chemoresistance in MI-BC cells. The gene discussed is CDK4; the disease is breast cancer.