TARDBP and amyotrophic lateral sclerosis: These aggregates were able to seed the fibrillization of endogenous TDP-43-HA and contained the pathological C-terminal fragments (CTFs) within the aggregates, even if, in this case, there was no evidence of hyperphosphorylation of the aggregated intracellular protein as it occurs in ALS and FTLD-TDP diseased brains [253].