Another group confirmed these results [223], showing that α-synuclein pathology caused the progressive loss of dopamine neurons in the substantia nigra pars compacta and caused impairment in motor coordination in mice injected with both pathological DLB brain-derived α-synuclein aggregates (i.e., the sarkosyl-insoluble fraction) and recombinant α-synuclein assemblies obtained in vitro. The gene discussed is SNCA; the disease is Lewy body dementia.