TARDBP and amyotrophic lateral sclerosis: Although initial pathological studies suggested that TDP-43 pathological aggregates displayed nonamyloid structures [257,258], a subsequent analysis showed the presence of amyloid structures in the spinal cord of a subset of ALS patients [259] and that the use of a different pretreatment of CNS tissues form ALS and FTLD-TDP patients allowed an increased detection of amyloid positive TDP-43 inclusions [260].