For instance, it was reported that the ciliopathy phenotype of Bardet-Biedl syndrome (bbs) and Oral-Facial-Digital Syndrome 1 (ofd1) morphant zebrafish embryos is ameliorated by injecting human proteasomal subunit component (RPN10, RPN13, or RPT6) mRNA or by injecting the proteasome activators sulforaphane (SFN) and mevalonolactone (alias mevalonic acid lactone, mevalonate, and (±)-β-hydroxy-β-methyl-δ-valerolactone and abbreviated MVA), respectively [66]. The gene discussed is PSMD4; the disease is Bardet-Biedl syndrome.