[13, 14] Conversely, the VUS detection rate is higher with the number of genes tested: BRCA1/2 alone (33/419 probands, 7.9%), 6-gene panel (42/419, 10.0%), 15-gene panel (74/419, 17.7%), 20-gene panel including Lynch Syndrome genes (90/419, 21.5%). Here, BRCA1 is linked to Lynch syndrome.