Following VacV-GP33 skin infection, expansion of WT, but not CD62L-/- P14 CD8+ T cells was observed in both the draining lymph node and in the spleen, whereas both WT and CD62L-/- naïve P14 CD8+ T cells expanded the same following systemic LCMV infection (Fig 2A and 2B). The gene discussed is SELL; the disease is skin infection.