Similar to the result acquired by IV labeling, the memory P14 CD8+ T cells in the skin that were eliminated by the Thy1.1 depleting antibody were mostly the CD69-/CD103- subset (Fig 4A–4D), whereas cells that expressed CD69 (both CD103+/-) were protected, suggesting that memory CD8+ T cells that expressed CD69 in the skin following clearance of a secondary viral infection were resident in the non-lymphoid tissue. This evidence concerns the gene CD69 and viral infectious disease.