MAPK8IP2, located about 70 kb proximal to SHANK3, and frequently co-deleted in PMS, is one such gene that has been implicated due to the high expressivity of the protein product in the brain at the post synaptic density, and studies showing mice with absence of MAPK8IP2 have abnormal dendritic morphology, as well as motor and cognitive deficits [29]. Here, MAPK8IP2 is linked to Cognitive impairment.