SHANK3, located at the terminal end of the Phelan-McDermid region, has been repeatedly implicated in the pathogenesis of neurodevelopmental disorders such as autism and intellectual disability [13], as well as psychiatric diseases such as schizophrenia [14, 15] and bipolar disorder [16]; its protein product known to play an important role in synaptic plasticity and maintenance of long term potentiation [17, 18]. This evidence concerns the gene SHANK3 and neurodevelopmental disorder.