Subsequent pathway analysis of this GWAS [30] tests approximately 4,000 pathways—182 containing FGFR2—and concludes that 86 of the top 100 pathways all contain FGFR2. Clearly a pathway is extremely likely to be found significant if it contains FGFR2, and thus pathways unrelated to breast cancer may be artificially driven to the top of the results based on the decision to include or exclude a single gene. Here, FGFR2 is linked to breast carcinoma.