To this end, we investigated bradykinin B1/B2 receptor (B1R/B2R)-deficient mice and wild-type mice treated with bradykinin receptor antagonists in an established model of respiratory tract infection with the common gram-negative pathogen Klebsiella (K.)pneumoniae resulting in a gradually growing bacterial load in the lungs with subsequent dissemination to distant body sites and sepsis. Here, BDKRB1 is linked to Sepsis.