CD274 and metastatic malignant neoplasm in the lymph nodes: Univariate and multivariate analyses of factors related to OS showed that PD-L1 positivity was an independent poor prognostic factor (hazard ratio [HR]: 1.97, 95% confidence interval [CI]: 1.18–3.20, p = 0.0106) along with diffuse histological type and the presence of lymph node metastasis (Table 2).