CXCR4 and Wilson disease: To determine the relevance of SDF-1 signaling in skin SCC growth and metastasis, we initially compared the expression of this chemokine and Cxcr4 and Cxcr7 receptors in early WD-SCCs and advanced PD/S-SCCs of two different lineages of mouse skin SCC progression (OT7 and OT14).