In accordance with the conserved epithelial differentiation traits of patient WD/MD-SCCs [11], hSCC24 WD cells expressed high levels of EpCAM and E-cadherin epithelial markers, whereas hSCC11 PD/S cells lost the expression of these epithelial markers and upregulated the expression of EMT-inducer transcription factors (Supplementary Fig. 6C and 6D). Here, CDH1 is linked to Wilson disease.