Previous reports described a functional crosstalk between PDGFR and CXCR4 signaling, as activation of PDGFR signaling promotes stability and phosphorylation of CXCR4 in medulloblastoma cells, inducing SDF-1/CXCR4 signaling [48, 49]. The gene discussed is CXCL12; the disease is medulloblastoma.