sh-CXCR4 tumors showed a reduced percentage of α6-integrin+/CXCR4+ tumor cells, and specifically of CXCR4-expressing CSCs, compared with sh-control tumors, whereas the percentage of CXCR7-expressing CSCs was not affected (Supplementary Fig. 3D–3F). The gene discussed is CXCR4; the disease is neoplasm.