IL10 and chronic rhinosinusitis: Recently, an IL-10 and TGF-β-producing ILC population was shown to regulate intestinal inflammation.83 Similarly, a small population of IL-10+ ILCs was detected in nasal tissue of patients with chronic rhinosinusitis with nasal polyps and in lungs of mice following repeated HDM inhalation, and retinoic acid was shown to induce IL-10 production from ILC2s expanded from human blood.84 Further studies will be required to evaluate the importance of IL-10+ ILCs in respiratory health and disease.