When we examined methylation patterns of these GWS CpG sites in relation to genotype, we determined that the methylation state of cg17426237 (PARG) was associated with rs2611513, which maps to PRKG1. Rs2611513 was nominally significantly associated to OD (β = 0.17, p = 0.02) in EAs in our published GWAS12; the OD risk allele is associated with decreased methylation at this CpG site. This evidence concerns the gene PRKG1 and osteochondritis dissecans.