On the HF diet, upregulated transcripts in DcnKO were enriched in the pathways, e.g. complement and coagulation cascades and platelet degranulation (Fig. 3B), while downregulated transcripts were enriched in the pathways, e.g., triglyceride biosynthesis and metabolism (Fig. 3B), supporting a role for decorin in adipose tissue lipid metabolism and inflammation. Here, DCN is linked to hydrops fetalis.