Oh et al.27 found the close correlations among PRC2 family proteins (EZH2, SUZ12, and EED), H3K27me3, c-MYC, Bcl-2, and Hox transcript antisense intergenic RNA (HOTAIR) in DLBCL tissues, and two possible pathways were proposed: (1) HOTAIR may induce the effect of H3K27me3 via mobilizing most inhibitor complexes, EZH2 methyltransferase and core proteins SUZ12 and EED; (2) the tumor gene c-MYC may induce the effect of H3K27me3 through the PRC2-related pathway in DLBCL. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.