Besides, the survival rate of lymphoma cells declines after MALAT-1 knockdown in drug-resistant cell lines, the proportion of cells in the G2/M phase decreases, and the expression levels of LC3-II/LC3-I increases and the expression level of p62 protein decreases, suggesting that inhibiting lncRNA MALAT-1 may strengthen the sensitivity of DLBCL to chemotherapy via enhancing autophagy. The gene discussed is MALAT1; the disease is lymphoma.