GSK3B and cancer: The Wnt signaling pathway is a well-known signaling pathway in the occurrence and development of cancer, whose specific process is as follows: Wnt protein binds to the seven-span transmembrane receptor in the frizzled family on the cell membrane, which delivers the signals into cells, activates the disheveled protein in the cytoplasm, inactivates the glycogen synthase kinase-3β (GSK-3β), and ensures that β-catenin in the cytoplasm is not degraded by GSK-3β.