SMAD5 and diffuse large B-cell lymphoma: The RT-qPCR results showed that the overexpression of SMAD5-AS1 in DLBCL cells could lead to the down-regulation of miR-135b-5p expression, while the down-regulation of SMAD5-AS1 could lead to the increase in miR-135b-5p expression (Fig. 5d).