EGFR and colonic neoplasm: In addition, some studies have reported that β-Thujaplicin can inhibit proliferation of human breast cancer MCF7 cells25, induces apoptosis of human colon cancer HCT-116 cells and teratocarcinoma F9 cells8,26, suppresses cancer stemness and oncogenicity in glioma stem U87MG and T98G cells27, and may have an ability to overcome EGFR-TKI resistance in lung adenocarcinoma PC9-IR and H1975 cells28.