Diffuse large B‐cell lymphomas also develop addiction to the mitochondrial protein deacetylase SIRT3 regardless of DLBCL mutation profile or cell‐of‐origin.126 SIRT3 stimulates glutaminolysis by directly activating mitochondrial glutamine dehydrogenase (GDH) to enhance TCA activity and generate alpha‐ketoglutarate (aKG) (Figure 3). This evidence concerns the gene SIRT3 and diffuse large B-cell lymphoma.