In part, this separation of anabolism and proliferation is due to the actions of the transcriptional repressor BCL6, which simultaneously silences MYC and multiple cell cycle checkpoint genes.48 Any loss of this MYC‐BCL6 mutual exclusivity is inherently dangerous and could unleash unlimited proliferation, as occurs in DLBCL and BL. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.