EZH2 and lymphoma: Perhaps a more precise approach for targeting the epigenome is provided by specific EZH2 inhibitors, which are particularly effective in suppressing EZH2 mutant lymphoma cells and EZH2 mutant lymphomas in humans.16, 187 Wildtype DLBCLs and FLs may also respond, given that EZH2 is an essential protein in GC B cells from which lymphomas arise.