NFKB1 and diffuse large B-cell lymphoma: Strikingly, more than 50% of genes mutated in DLBCL are transcription factors or chromatin modifiers.57, 59 There are frequent mutations of immune signaling pathway genes including antigen presentation, BCR signaling, NF‐κB signaling, PI3K, Toll‐like receptor (TLR), and NOTCH signaling.