This finding was corroborated in vitro in Jurkat and lung adenocarcinoma cell lines exposed to 0.1 and 1 nM of benzo[a]pyrene, in which a promoter hypermethylation and a reduced expression of IFNγ, but not interleukin 4 (IL4), were observed [43]. Here, IL4 is linked to lung adenocarcinoma.