In conclusion, in this study, we found eleven cytokines (IFNGR1, Notch‐3, TNFRSF19L, GHR, SLAMF8, FR‐beta, integrin alpha 5, galectin‐8, EphA1, epiregulin, and FGF‐12) that were elevated in gastric cancer serum, suggesting that these cytokines may participate in the occurrence and development of gastric cancer. Here, RELT is linked to gastric cancer.