SLAMF8, the eighth member of the SLAMF costimulatory receptors, regulates the development and function of many immune cells.14, 15, 16 Although Zou et al17 reported SLAMF8 as an independent prognosis factor in glioma and Sasaroli et al18 found SLAMF8 was increased in ovarian cancer, there have been few reports on the relationship of SLAMF8 and gastric cancer. Here, SLAMF8 is linked to gastric cancer.