In conclusion, in this study, we found eleven cytokines (IFNGR1, Notch‐3, TNFRSF19L, GHR, SLAMF8, FR‐beta, integrin alpha 5, galectin‐8, EphA1, epiregulin, and FGF‐12) that were elevated in gastric cancer serum, suggesting that these cytokines may participate in the occurrence and development of gastric cancer. This evidence concerns the gene ITGA5 and gastric cancer.