ESR1 and cancer: However, TP53 mutation has been associated with tumourigenesis and carcinomatous metastasis.18, 19 ERBB2 (receptor tyrosine‐protein kinase erbB‐2) is a member of the epidermal growth factor receptor that promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth.20 In human study, elevated positive proteins of neoplastic ESR1, TP53, ERBB2 were observed in OGS samples, followed by abnormal cancer antigen contents in blood samples.