AKT1 and cancer: Additionally, there have been an increasing number of studies on the use of combination therapies to treat cancer using DNA repair mechanisms.34, 35, 36 Research has shown that the inactivation of AKT results in dephosphorylation and activation of FOXO transcription factors, which is involved in mediating cell cycle arrest, DNA repair and apoptosis.31, 32 It would be feasible to make a combination therapy via DNA repair progression.