Several pathways have been reported to be related to malignant tumour function, such as the modulation of Slug/E‐cadherin,31 PI3K‐Akt32 and MEK‐ERK.33 Because the PI3k‐AKT pathways were activated and upregulated by CRT and the expression of E‐cadherin and ERK was not impacted by miR‐944 in this study, we performed an immunoprecipitation experiment in HCT116 and SW480 cells and found that CRT is structurally associated with AKT. The gene discussed is MAP2K7; the disease is cancer.