GATA transcription factors are a series of zinc finger proteins that can determine the consensus DNA sequence WGATAA.22 The GATA family consists of six members (GATA1‐6),23 and GATA6 is located on 18q11.2 and participates in cell differentiation of the splanchnic mesoderm, such as the lung and gastrointestinal track.24 Emerging evidence has shown that GATA6 acts as a tumour promoter in CRC. The gene discussed is ZNF146; the disease is colorectal carcinoma.