GATA6 and cancer: Dysregulation of GATA6 expression has been shown to be significantly associated with liver metastasis (P = 0.001) and poor overall survival (OS) (P < 0.001), and knockdown of GATA6 has been shown to suppress cancer cell invasion.16 However, the mechanism by which overexpression of GATA6 inhibits the initiation and progression of CRC is not known.