Overall, Hispanics have a lower incidence of cancers associated with circulating IGF concentrations, in comparison with non‐Hispanic whites, while African Americans have an increased incidence of prostate cancer.11, 12 In Hispanics, the reduction in both IGF‐I and IGFBPs may reduce the concentration of bioavailable IGF‐I, whereas the lower concentrations of IGFBPs in African Americans might lead to an increase in bioavailable IGF‐I. Here, IGF1 is linked to Familial prostate cancer.