MTOR and hepatocellular carcinoma: In Kunming mice, high (20 mg/kg) and low (10 mg/kg) doses of PESV or PESV in combination with Rapamycin (mTOR inhibitor; 2 mg/kg) administered via gastrogavage for 14 successive days downregulated the expression of mTor and inhibited the growth of the murine hepatoma (H22) cells, leading to a reduction in tumor weight and volume [22].