Another study highlighting the importance of TNF-α in RA vis-á-vis FoxP3+ Tregs reported that overexpression of TNF-α in human TNF-α transgenic mice led to the development of arthritis, with an increased number of Tregs expressing the TNF receptor II (TNFRII) [43]. The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.