TNF and rheumatoid arthritis: Medications used in the treatment of RA include non-steroidal anti-inflammatory drug (NSAIDs), disease-modifying anti-rheumatic drug (DMARDs), TNF-α inhibitors, IL-6 inhibitors, T-cell activation inhibitors, B-cell depletors, Janus kinase (JAK) inhibitors, and steroids [10] (Figure 1).