A search was performed in the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed/) in February 2016, using the following key words, “glioblastoma”, “EGFRvIII”, “epidermal growth factor receptor variant III”, “VEGF”, “PTEN”, “mTOR”, “Akt”. The gene discussed is AKT1; the disease is glioblastoma.