Previously, The Cancer Genome Atlas identified mutations in cohesin in 26 out of 200 (13%) primary AML adult patients, with a higher mutations frequency in STAG2, SMC1A, SMC3, RAD21 meanwhile no mutation in STAG1 were observed in comparison to Thol and colleagues’ analysis (Ley et al., 2013; Thol et al., 2014). This evidence concerns the gene SMC3 and acute myeloid leukemia.