The interaction between cohesin and Wnt/beta-catenin signaling has been described in different models of cancer (Ghiselli et al., 2003), and in our zebrafish model with cohesin haploinsufficiency (Pistocchi et al., 2013; Fazio et al., 2016; Mazzola et al., 2019), suggesting a possible effect of cohesin mutations and Wnt/beta-catenin signaling dysregulation in DS-AMKL. This evidence concerns the gene CTNNB1 and cancer.