The analysis of CDKN2A, KRAS, MYC, SMAD4, TP53 genes, whose alterations are known to contribute to PDA development (34, 35) showed a significantly higher expression of CDKN2A and KRAS and a lower expression of SMAD4 and TP53 (Figure 1C). The gene discussed is SMAD4; the disease is Patent ductus arteriosus.