Metabolic and glycolytic enzymes, including Phosphoglycerate Kinase 1 (PGK1) Triose Phosphate Isomerase 1 (TPI1), Glucose-6-phosphate dehydrogenase (G6PD), Isocitrate dehydrogenase (IDHC), and Enolase 1 (ENO1) are highly expressed in PDA and they induce autoantibody and/or T cell responses in PDA (40–44). The gene discussed is TPI1; the disease is Patent ductus arteriosus.