TP53 and cancer: These include the Oncopig Cancer Model—a transgenic pig model that recapitulates human cancer through induced expression of heterozygous KRASG12D and TP53R167H driver mutations—which has been utilized to develop HCC (35), pancreatic cancer (36), and soft-tissue sarcomas (37, 38), and a heterozygous TP53 knockout model of spontaneous osteosarcomas (39).