PIN1 and early-onset autosomal dominant Alzheimer disease: Of note, the rs2233678 polymorphism in the human PIN1 promoter is associated to decreased gene expression and to a lower risk of breast (50) and lung (51) cancer incidence, while the rs2287839 polymorphism hampers suppression of PIN1 transcription by the AP4 transcription factor and correlates with delayed onset of Alzheimer's disease (52).