Of note, PIN1 crucially impacts EGFR-promoted Warburg effect in cancer cells by inciting nuclear localization of the Pyruvate Kinase 2 (PKM2), which induces c-MYC expression, resulting in turn in the upregulation of the glucose transport protein 1 (GLUT1) and lactate dehydrogenase A (LDHA) (76). The gene discussed is PKM; the disease is cancer.