MDM2 inhibitors e.g., Nutlin-3a, SAR405838, and JNJ-26854165, or c-Abl kinase inhibitor e.g., Nilotinib, can suppress the growth of lymphomas in EμEBNA-1 transgenic mice via the EBNA-1/MDM2/E2F1 pathway (98). The gene discussed is E2F1; the disease is lymphoma.