Some limitations need to be considered, for example, the present study does not strongly confirm the roles of chemerin/CMKLR1 on exercise-induced improvement of glycolipid metabolism and its possible mechanism in obesity and diabetes rats, for lacking rat-specific commercial exogenous chemerin as well as agonist and antagonist of CMKLR1. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.