Therefore, the purpose of the current study was to verify: 1) if exercise reduced chemerin and CMKLR1in the peripheral metabolic organs (not only serum chemerin) of obesity and diabetes rats; 2) if exercise-induced decreases of chemerin/CMKLR1 were mediated by PPARγ in the diabetes rats. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.