Circulating chemerin is elevated in numerous metabolic and inflammatory diseases including obesity [4], metabolic syndrome [5], type 2 diabetes [6], atherosclerosis [7, 8], hypertension [9], cardiovascular disease [8, 10] and nonalcoholic fatty liver disease [11, 12], and the chemerin level is associated with symptoms severity of these inflammatory diseases [13]. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.