Although most reports including ours supported the promotion effects of chemerin/CMKLR1 on the disorder of glycolipid metabolism and inflammatory, but some studies suggested an anti-inflammatory effect of chemerin/CMKLR1 [42] and a positive effect of CMKLR1 on glycolipid metabolism because CMKLR1(−/−) mice exhibited HFD-induced exacerbation of glucose intolerance, increase of insulin level and promotion of IR [43]. Here, INS is linked to Glucose intolerance.