RARRES2 and obesity due to melanocortin 4 receptor deficiency: The present study broadened the increases of chemerin in the obesity and diabetes rats from serum, liver to gastrocnemius, and found a potential concentration-dependent relationship between chemerin and the disorder of glycolipid metabolism according to the gradual increment of chemerin levels (Con rats<OB rats<DM rats) in the serum and metabolic organs, accompanied with the rising disorders of glycolipid metabolism.