It had been demonstrated that serum chemerin was reduced by exercise, such as 12 week Nordic walking in overweight and obese men [21], 6-month combined endurance and strength training in obese adults [23], 1 year regular moderate walking in the patients with type 2 diabetes [22], even an acute bout of aerobic exercise in obese adults [45]. Here, RARRES2 is linked to type 2 diabetes mellitus.