PPARG and type 2 diabetes mellitus: Exercise increased the levels of PPARγ in the livers, skeletal muscle and circulating monocytes, which might be related to the decreases of IR and hepatic lipid content [49] and enhancements of glucose uptake and fatty acid oxidation of skeletal muscle in obese Zucker rats [32], as well as the decrease of IR and prevention of type 2 diabetes in human [31].