Besides, exercise-induced attenuation of chemerin in serum has been demonstrated to alleviate IR and subclinical inflammation in overweight and obese type 2 diabetes patients [46–48], and the present study first broaden the effects of reduced chemerin on the improvement of glycolipid metabolism from serum to peripheral metabolic organs, and first reported the exercise-induced decrease of CMKLR1 in metabolic organs, which was one significance of the present study. This evidence concerns the gene RARRES2 and type 2 diabetes mellitus.