Among these lncRNAs, MBNL1-AS1, HAND2-AS1, and RP11-999E24.3 were most down-regulated and PSMB8-AS1, LINC01094, and RP11-389C8.2 were most up-regulated lncRNAs in advanced atherosclerosis patients. The gene discussed is PSMB8; the disease is atherosclerosis.